Selected Publications
Cardiac myosin-binding protein C: how a novel biomarker could transform chest pain triage
Chest pain is a common symptom – according to recent literature, it is responsible for at least 6% of all presentations to emergency departments – however, only about 10% of these patients have a final diagnosis of acute myocardial infarction (AMI). Chest pain triage is fraught with difficulties as physicians are increasingly caught at the interplay of sensitivity and specificity.
In Biomark Med,
2018
Direct Comparison of Cardiac Myosin-Binding Protein C With Cardiac Troponins for the Early Diagnosis of Acute Myocardial Infarction
Diagnostic accuracy of cardiac myosin-binding protein C for acute myocardial infarction was similar to that of high-sensitivity cardiac troponin T and high-sensitivity cardiac troponin I in the entire cohort but superior for those with chest pain of <3 hours (early presenters) when compared with high-sensitivity cardiac troponin T. Cardiac myosin-binding protein C has correctly triaged more patients to rule-out or rule-in groups than either high-sensitivity cardiac troponin I or high-sensitivity cardiac troponin T, leaving a much smaller proportion in the observation groups. This advantage may facilitate early discharge of low-risk patients.
In Circulation,
2017
